registered to practice before the U.S. Patent and Trademark Office Education: Ashland University (B.S., Biology); University of Toledo (M.S., Pharmacology); Emory University (Ph.D., Pharmacology, 2008).
Michele A. Kliem, Ph.D. is a patent agent for Duane Morris' Intellectual Property Practice Group, in which capacity she assists attorneys with patent prosecution and litigation. Dr. Kliem's background includes extensive pharmacological laboratory work. Dr. Kliem's research in neuroscience focused on the role of the basal ganglia in the modulation of movement under normal conditions and in Parkinson's disease. She designed a combination microelectrode recording-injection device to deliver very small quantities of drugs to locally test their effects on cellular discharge properties of individual neurons in vivo. These experiments were carried out along with a series of microdialysis and electron microscopy studies to better understand the function and location of dopamine receptors and their role in the modulation of GABA neurotransmission.
Dr. Kliem currently holds a faculty position at the Georgia Institute of Technology Department of Applied Physiology where she teaches a Health Performance Science course. Her experience also includes working as a pharmacologist for Eli Lilly and Co.
Dr. Kliem received a Ph.D. in pharmacology from Emory University in 2008. She completed her postdoctoral studies at Emory University Department of Neurosurgery. Dr. Kliem's postdoctoral research focused on the delivery of molecular therapeutics to anatomically defined targets for the treatment of neurodegenerative disorders. She concentrated on therapies (drug-loaded polyketal microparticles and bacterial plasmids) aimed to improve motor disability associated with Amyotrophic Lateral Sclerosis using a transgenic rat model of the human disease. She also holds an M.S. in pharmacology from the University of Toledo and a B.S. in biology from Ashland University.
· Society for Neuroscience
· International Basal Ganglia Society
· Co-author, "Addressing Breach of Method-of-Use Patents by Generics," Law360, May 2, 2012
· Co-author, "Federal Circuit Addresses Infringement of Method-of-Use Patents by Generics in Yasmin® Case," Duane Morris Alert, April 18, 2012
· Wichmann T., Kliem M.A., DeLong M.R. "Antiparkinsonian and Behavioral Effects of Inactivation of the Substantia Nigra Pars Reticulata in Hemiparkinsonian Primates," Experimental Neurology, Vol. 167, pp. 410-424, 2001.
· Wichmann T., Kliem M.A., Soares J. "Slow oscillatory discharge in the primate basal ganglia," Journal of Neurophysiology, 87(2):1145-8, 2002.
· Wichmann T. and Kliem M.A. "Neuronal Activity in the Primate Substantia Nigra Pars Reticulata During the Performance of Simple and Memory-Guided Elbow Movements," Journal of Neurophysiology, 91:815-827,2004.
· Soares J., Kliem M.A., Betarbet R., Greenamyre J.T., Yamamoto B., Wichmann T. "Role or External Pallidal Segment in Primate Parkinsonism: Comparison of the Effects of I-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Parkinsonism and Lesions of the External Pallidal Segment," Journal of Neuroscience, 24(29):6417-6426, 2004.
· Kliem M.A. and Wichmann T. "A Method to Record Changes in Local Neuronal Discharge in Response to Infusion of Small Drug Quantities in Awake Monkeys," Journal of Neuroscience Methods, 138:45- 49,2004.
· Galvan, A., Kliem, M.A., Smith, Y. and Wichmann, T. "Gabergic and Dopaminergic Modulation of Basal Ganglia Output in Primates," The Basal Ganglia VIII, editors Bolam, Magill and Ingram, 2005.
· Kliem, M.A., Maidment, N.T., Ackerson, L.C., Chen, S., Smith, Y., Wichmann T. "Activation of Nigral and Pallidal Dopamine Dl-Like Receptors Modulates Basal Ganglia Outflow in Monkeys," Journal of Neurophysiology, 98:1489-1500, 2007.
· Kliem, M.A., Pare J-F, Khan ZU, Wichmann T and Smith Y. "Comparative Ultrastructural Analysis of D1 and D5 Dopamine Receptor Distribution in the Substantia Nigra and Globus Pallidus of Monkeys," The Basal Ganglia IX, editors Berendse, Cools, Voorn and Mulder, 2008.
· Kliem, M.A. and Wichmann T. "Basal Ganglia: Functional Models of Normal and Disease States," In: Squire L.R. (ed.) Encyclopedia for Neuroscience, Volume 2, p. 87-92, Oxford: Academic Press, 2009.
· Kliem. M.A. and Wichmann T. "Basal Ganglia: Functional Models of Normal and Disease States," In:Handbook of the Neuroscience of Aging, ed. Patrick R. Hof and Charles V. Mobbs, (p.229-234). San Diego: Academic Press, 2009.
· Franz, C.K., Quach, E.T., Krudy, C.A., Federici, T., Kliem, M.A., Snyder, B.R., Roare, B., and Boulis, N.M. "A Conditioning Lesion is Protective in a Model of Amyotrophic Lateral Sclerosis," PLoS ONE, 4(10): e7357. doi:10.137//journal.pone.0007357, 2009.
· Kliem, M.A., Pare J-F, Khan ZU, Wichmann T and Smith Y. "Ultrastructural Localization and Function of Dopamine D1-Like Receptors in the Substantia Nigra Pars Reticulata and the Internal Segment of the Globus Pallidus of Parkinsonian Monkeys," European Journal of Neuroscience, 31:836-851, 2010.
Selected Speaking Engagements
· "Effects of Dopamine D1-like Receptor Activation in the GPi and SNr of Normal and Parkinsonian Primates," Invited Speaker, Department of Applied Physiology, Georgia Institute of Technology, 2007
· "Effects of Dopamine D1-like Receptor Activation in the GPi and SNr of Normal and Parkinsonian Primates," Invited Speaker, Cleveland Clinic Foundation, Departments of Neuroscience and Neuroengineering, 2007